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| First Name: | Andrew | | Last Name: | McCaddon | | Title: | Dr | | Advanced Degrees: | BSc(Hons) MB ChB MRCGP MD | | Affiliation: | University of Wales College of Medicine | | Department: | General Practice | | Street Address 1: | Gardden Road Surgery | | Street Address 2: | Rhosllanerchrugog | | City: | Wrexham | | State/Province: | Wales | | Zip/Postal Code: | LL14 2EN | Country/Territory: | United Kingdom | | Phone: | 01978 840034 | | Fax: | 01978 845782 | | Email Address: |  |
Disclosure:
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Member reports the following financial or other potential conflicts of interest: [Last Modified: 6 June 2005]
I am a Scientific Advisor and shareholder of COBALZ Limited (www.cobalz.co.uk), a UK-based company developing glutathionylcobalamin as an alternative orally available form of vitamin B12.
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View all comments by Andrew McCaddon
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Aging Process, Alzheimer Disease
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Oxidative Stress, Chemistry/Pharmacology, Epidemiology, Homocysteine, Neurobiology
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General Practioner in North Wales with an interest in the association between Alzheimer's disease and disturbances of single-carbon metabolism (ie folate/B12 deficiencies) |
1: McCaddon A, Regland B, Hudson P, Davies G. Functional vitamin B(12) deficiency and Alzheimer disease.
Neurology. 2002 May 14;58(9):1395-9.
PMID: 12011287 [PubMed - indexed for MEDLINE]
2: McCaddon A, Blennow K, Hudson P, Regland B, Hill D.
Transcobalamin polymorphism and homocysteine.
Blood. 2001 Dec 1;98(12):3497-9.
PMID: 11732507 [PubMed - indexed for MEDLINE]
3: McCaddon A, Hudson P, Davies G, Hughes A, Williams JH, Wilkinson C. Homocysteine and cognitive decline in healthy elderly.
Dement Geriatr Cogn Disord. 2001 Sep-Oct;12(5):309-13.
PMID: 11455131 [PubMed - indexed for MEDLINE]
4: McCaddon A, Hudson P, Abrahamsson L, Olofsson H, Regland B. Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease. Dement Geriatr Cogn Disord. 2001 Mar-Apr;12(2):133-7.
PMID: 11173886 [PubMed - indexed for MEDLINE]
5: McCaddon A, Davies G, Hudson P. Nutritionally independent B12 deficiency and Alzheimer disease.
Arch Neurol. 2000 Apr;57(4):607-8. No abstract available.
PMID: 10768642 [PubMed - indexed for MEDLINE]
6: McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry. 1998 Apr;13(4):235-9.
PMID: 9646150 [PubMed - indexed for MEDLINE]
7: McCaddon A, Regland B, Fear CF. Trypsin inhibition: a potential cause of cobalamin deficiency common to the pathogenesis of Alzheimer-type dementia and AIDS dementia complex?
Med Hypotheses. 1995 Aug;45(2):200-4. Review.
PMID: 8531843 [PubMed - indexed for MEDLINE]
8: McCaddon A, Kelly CL. Related Articles
Familial Alzheimer's disease and vitamin B12 deficiency. Age Ageing. 1994 Jul;23(4):334-7.
PMID: 7976784 [PubMed - indexed for MEDLINE]
9: Kennedy AM, Newman S, McCaddon A, Ball J, Roques P, Mullan M, Hardy J, Chartier-Harlin MC, Frackowiak RS, Warrington EK, et al. Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).
Brain. 1993 Apr;116 ( Pt 2):309-24.
PMID: 8461968 [PubMed - indexed for MEDLINE]
10: McCaddon A, Kelly CL. Alzheimer's disease: a 'cobalaminergic' hypothesis.
Med Hypotheses. 1992 Mar;37(3):161-5. Review.
PMID: 1350050 [PubMed - indexed for MEDLINE]
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The "key-events" or trigger factor(s) underlying this pathological cascade. |
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